WHAT TO EXPECT

What to expect

Not an actual patient.

Knowing what to expect can make a real difference

Feeling informed about starting LUPRON DEPOT is a positive first step in your treatment experience.

Information to help you learn more about your treatment

Syringe

How it’s given

LUPRON DEPOT is given as an intramuscular injection by a healthcare professional at your doctor’s office.¹

LEARN HOW

Insurance Card

Insurance coverage

LUPRON DEPOT is widely covered by Medicare and commercial insurance.²

OPTIONS

Symptoms

During the first few weeks of therapy, your testosterone levels may rise before they fall. As a result, you may temporarily experience new or worsening symptoms of prostate cancer, including urinary symptoms and bone pain. Notify your doctor if you develop any new or worsened symptoms after beginning treatment with LUPRON DEPOT.¹

MANAGE SIDE EFFECTS

Tips for getting off to a positive start with LUPRON DEPOT

Take an active role in your treatment

Communicate openly with your doctor. Ask questions, share any concerns, and reach out if your experience with LUPRON DEPOT changes. A proactive approach can help you feel more in control.

Commit to your treatment plan and scheduled visits with your doctor

Get all of the doses your doctor prescribes, so you can get the most from your LUPRON DEPOT therapy.

If you experience side effects, speak up!

Talk to your doctor, as they may have some ideas for helping to manage side effects. It’s also important to let your healthcare team know if you experience new or worsening symptoms.

Don HS

Individual results may vary.

“After talking about it with my doctor, we decided to start out on the 6-month dose, which is only 2 times per year. My doctor said we can switch to a more frequent dose if we need to, such as if I need my testosterone and PSA levels tested more often.”

– Don, LUPRON DEPOT advanced prostate cancer patient

Support PLUS program

Learn about connecting with a Support PLUS Specialist* and how they can help, or call

844-458-7876

*Support PLUS Specialists are provided by AbbVie and do not work under the direction of a healthcare professional (HCP) or give medical advice. They are trained to direct patients to speak with their HCP for treatment-related advice, including further referrals. To learn about AbbVie’s privacy practices and your patient’s privacy choices, visit www.abbvie.com/privacy.html.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.

References

LUPRON DEPOT [package insert]. North Chicago, IL: AbbVie Inc; 2025.
Data on file, AbbVie Inc. Medical Benefit, 2024.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.