WHAT IS LUPRON DEPOT?

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Not an actual patient.

A proven treatment with trusted experience¹

You trust your doctor. Doctors count on LUPRON DEPOT for the treatment of advanced prostate cancer, which has been committed to helping patients like you for 40 years.^2*

*FDA approved in 1985.

What Is LUPRON DEPOT?

LUPRON DEPOT is in the class of hormonal therapyHormonal therapy
Treatment with drugs that interfere with hormone production or hormone action, or the surgical removal of hormone-producing glands.³ drugs called gonadotropin-releasing hormone agonists GnRH agonists
These are synthetically made hormones, chemically similar to natural gonadotropin-releasing hormones (GnRH). With continuous use in men, they block the production of the male hormone testosterone by the testicles and are frequently used in the treatment of advanced prostate cancer.^1,4

(also called GnRH agonists or GnRHa).¹

Although LUPRON DEPOT is not a cure for advanced prostate cancer, you and your doctor may choose LUPRON DEPOT as part of your treatment plan to suppress testosterone that may cause testosterone-dependent prostate cancer cells to grow.¹

DO NOT TAKE IF you have had any type of allergic reaction to LUPRON DEPOT or similar drugs.¹

How LUPRON DEPOT Works

LUPRON DEPOT lowers your testosterone levels to slow the growth of testosterone-dependent prostate cancer cells.¹

TestosteroneTestosterone
A male sex hormone produced primarily by the testicles that is important in male physical and sexual function and development.⁵ feeds the growth of prostate cancer cells.⁵

Prostate cancer cells

With LUPRON DEPOT treatment, testosteroneTestosterone
A male sex hormone produced primarily by the testicles that is important in male physical and sexual function and development.⁵ levels are reduced.¹

Without treatment, testosteroneTestosterone
A male sex hormone produced primarily by the testicles that is important in male physical and sexual function and development.⁵ levels are sustained.

Without treatment, testosteroneTestosterone
A male sex hormone produced primarily by the testicles that is important in male physical and sexual function and development.⁵ levels are sustained.

Prostate cancer cells continue to grow

With LUPRON DEPOT treatment, testosteroneTestosterone
A male sex hormone produced primarily by the testicles that is important in male physical and sexual function and development.⁵ levels are reduced.¹

Lower testosterone slows the growth of prostate cancer cells

For illustrative purposes only.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.

References

LUPRON DEPOT [package insert]. North Chicago, IL: AbbVie Inc; 2025.
Drugs@FDA: FDA-approved drug products. US Food & Drug Administration. Accessed March 7, 2025. https://www.accessdata.fda.gov/scripts/cder/daf/
National Cancer Institute (NCI). Dictionary of cancer terms: hormonal therapy. Accessed March 7, 2025. Available at https://www.cancer.gov/publications/dictionaries/cancer-terms
Urology Care Foundation. Prostate cancer – advanced. Published April, 2024. Accessed March 7, 2025. https://www.urologyhealth.org/urology-a-z/a_/advanced-prostate-cancer
Prostate Cancer Foundation of Australia. Understanding hormone therapy for prostate cancer. Accessed March 7, 2025. https://issuu.com/prostatecancerfoundationaus/docs/pcf13461_-_04_-_understanding_hormone_therapy_34_p

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.