HOW LUPRON DEPOT IS GIVEN

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Not an actual patient.

LUPRON DEPOT is given at your doctor’s office

LUPRON DEPOT is administered as an intramuscular injection by a healthcare professional at your doctor’s office. Your doctor will determine the most appropriate injection site for you.¹

Possible injection sites include¹:

number 1

Upper arms

number-2

Upper lateral thighs

number-3

Buttocks

number 4

Outer lateral thighs

Illustrated graphic of a silhouette of a man with numbered circles indicating possible injection sites: 1. Upper arms 2. Upper lateral thighs 3. Outer lateral thighs 4. Buttocks

Flexible dosing options for your treatment needs

LUPRON DEPOT offers 4 dosing options. You and your doctor can choose the option that works best for you.¹

Every

6 months

2x per year

Every

4 months

3x per year

Every

3 months

4x per year

Every

month

12x per year

Each dosing option has been studied in clinical trials and is proven effective at keeping your testosterone suppressed between doses.¹

With that in mind, it’s important that you keep each scheduled visit, so your doctor can monitor how well your treatment is working. Your doctor may choose to change your dosing frequency based on your treatment needs.

Don HS

Individual results may vary.

“After talking about it with my doctor, we decided to start out on the 6-month dose, which is only 2 times per year. My doctor said we can switch to a more frequent dose if we need to, such as if I need my testosterone and PSA levels tested more often.”

- Don, LUPRON DEPOT advanced prostate cancer patient

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.

Reference

LUPRON DEPOT [package insert]. North Chicago, IL: AbbVie Inc; 2025.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month,  22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration  are prescribed for the treatment of advanced prostate cancer. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision. LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage. Worsening of symptoms or onset of new signs and symptoms during the first few weeks of treatment, including bone pain, neuropathy, hematuria, or bladder outlet obstruction.

USE

LUPRON DEPOT^® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the treatment of advanced prostate cancer.
LUPRON DEPOT is a prescription medication that must be administered under your doctor’s supervision.

IMPORTANT SAFETY INFORMATION

LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
- Some men may experience temporary new or worsening symptoms of prostate cancer, including bone pain, urine outlet blockage, blood in urine, and numbness and/or pain from nerve damage.
- If your cancer has spread to the spine, this may lead to paralysis, which may be life-threatening.
- You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
High blood sugar, increased risk of diabetes, high lipids (such as cholesterol and triglycerides), and/or the accumulation of liver fat without drinking alcohol can occur in men using LUPRON DEPOT. Your doctor will monitor for these changes.
Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
Treatment with LUPRON DEPOT may cause severe skin reactions that can be life-threatening or fatal. Get medical help right away if you develop any signs or symptoms of a severe skin reaction, including fever or flu-like symptoms; blisters in the mouth, nose, throat, or eyes; severe rash or rash that continues to get worse; sores or blistering or peeling of the skin; or swollen lymph nodes.
LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
LUPRON DEPOT may cause impotence.
The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

US-LUPR-240147

Please click here for full Prescribing Information or visit https://www.rxabbvie.com/pdf/lupronuro_pi.pdf.