The most common side effects of LUPRON DEPOT include*:

  • Hot flashes or sweats
  • Injection-site reactions or pain
  • General pain
  • Swelling
  • Testicular shrinkage
  • Difficulty urinating
  • Fatigue or weakness
  • Headache
  • Joint, gastrointestinal (GI),
    and respiratory problems

*Side effects reported in at least 5% of patients in the clinical trials.

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Safety considerations

  • While LUPRON DEPOT ultimately reduces testosterone in your body, during the first few weeks of therapy, your testosterone levels may rise before they fall. You may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and bone pain
  • High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. (Your doctor will monitor your blood sugar during treatment)
  • An increased risk of heart attack, sudden death, and stroke can also occur. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment
  • Reports of convulsions have occurred in patients taking LUPRON DEPOT with or without a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medicines that cause convulsions
  • You should also know that LUPRON DEPOT may cause impotence and infertility

Other important considerations

  • Treatment affects all men differently. Talk to your doctor about your medical history and all other medicines you take
  • LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat
  • If you are concerned about any side effects or new symptoms during your LUPRON DEPOT treatment, it’s important to discuss them with your doctor right away.