Dosing Options
to Individualize
Patient Care

Lucas, age 64
Semiretired financial analyst,
passionate cook,

husband, father

Not an actual patient.

Choose the dosing schedule that’s right for each of your patients with advanced prostate cancer. Four in-office dosing options help you meet individual patient needs and schedule regular monitoring.

Four In-Office Dosing Options

2019 label update: Dosing in nonmetastatic disease

The dosage and administration information in the Prescribing Information for LUPRON DEPOT was amended to include continuation of treatment upon development of nonmetastatic castration-resistant prostate cancer1

Dosing in non-metastatic disease

In patients treated with GnRH analogues for prostate cancer, treatment is usually continued upon development of non-metastatic and metastatic castration-resistant prostate cancer.1

6 month

45-mg injection every 6 months

2x per year

3 month

22.5-mg injection every 3 months

4x per year

4 month

30-mg injection every 4 months

3x per year

1 month

7.5-mg injection every month

12x per year

3 month

22.5-mg injection every 3 months

4x per year

1 month

7.5-mg injection every month

12x per year

An All-In-One Syringe

Simple delivery system

  • Prefilled dual-chamber syringe1
    • ‒ No external mixing needed
    • ‒ Ready to inject immediately following preparation
    • ‒ Administration should be within 2 hours of reconstitution
  • No refrigeration required1
    • ‒ No need to warm prior to administration
  • Closed-system transfer device (CSTD)2*

Built-in safety mechanism

  • First product in class to offer LuproLoc® safety device1
  • Helps prevent needlestick injuries1,3

Patient experience in mind

  • Fine 23-gauge, 1.5-inch IM needle for all dosing options4

Safety considerations

Injection site reactions and injection site pain/discomfort were experienced in clinical trials.

*Mechanically prohibits the transfer of environmental contaminants into the system and the escape of hazardous drug or vapor concentrations outside the system.

Learn How to Mix and Administer LUPRON DEPOT

Download and print step-by-step mixing and administering instructions.

Because the dual-chamber syringe requires no external mixing, all mixing
takes place within the prefilled syringe in 3 steps.

*Reconstitution and administration for injection of LUPRON DEPOT requires a
total of 10 steps; of those, only 3 are for suspension mixing.

*Adapted from section 2.5, steps 2-4 of the LUPRON DEPOT package insert:

To prepare for injection, screw the white plunger into the end stopper until the stopper begins to turn.

Hold the syringe UPRIGHT. Release the diluent by SLOWLY PUSHING (6 to 8 seconds) the plunger until the first middle stopper is at the blue line in the middle of the barrel.

Keep the syringe UPRIGHT. Mix the microspheres (powder) thoroughly by gently shaking the syringe until the powder forms a uniform suspension. The suspension will appear milky. If the powder adheres to the stopper or caking/clumping is present, tap the syringe with your finger to disperse. DO NOT USE if any of the powder has not gone into suspension.1