You trust your doctor. Doctors count on Lupron Depot

For over 25 years ,doctors still choose LUPRON DEPOT to treat their patients with
advanced prostate cancer.3

What is Lupron Depot?

LUPRON DEPOT is in the class of hormonal therapy drugs called gonadotropin-releasing hormone agonists (also called GnRH agonists or GnRHa),3 While Lupron is not a cure for advanced prostate cancer, you and your doctor may choose LUPRON DEPOT as part of your treatment plan to suppress testosterone that may cause testosterone-dependent prostate cancer cells to grow.1,4

DO NOT TAKE IF

You should not take LUPRON DEPOT if you have had any type of allergic reaction to LUPRON DEPOT or similar drugs.

HOW LUPRON DEPOT WORKS

Most prostate cancer cells depend on testosterone (the male sex hormone) to grow. LUPRON DEPOT suppresses the production of testosterone, which slows the growth of prostate cancer cells.1,4

Dosing options for your treatment needs1

 

LUPRON DEPOT offers multiple dosing options, so your doctor can choose the right dose for you based on your individual treatment needs. Each dosage is given as a single intramuscular injection, and has been studied in clinical trials and prescribed by doctors. You and your doctor will decide which dosage of LUPRON DEPOT is right for you.


This chart shows what treatment with each dose may look like over the course of one year.



Each dose of LUPRON DEPOT works to suppress testosterone during your treatment period, so it’s important that you keep each scheduled visit so your doctor can monitor how well your treatment is working.1  With that in mind, over the course of your treatment, your doctor may choose to change your dosage frequency to align with your treatment needs.

HOW LUPRON DEPOT IS GIVEN

LUPRON DEPOT is a prescription medicine that must be administered under the supervision of a physician. It’s given as a single intramuscular injection, which means it is injected into one of your muscles, instead of under the skin or into a vein. Your doctor will determine the most appropriate injection site for you.1

The most common side effects of LUPRON DEPOT include:1

 

•  Hot flashes or sweats

•  Injection site reactions or pain

•  General pain

•  Swelling

•  Testicular shrinkage

•  Difficulty urinating

•  Fatigue or weakness

•  Headache

•  Joint, gastrointestinal (GI), and respiratory problems

 

SAFETY CONSIDERATIONS

While LUPRON DEPOT ultimately reduces testosterone in your body, during the first few weeks of therapy, your testosterone levels may rise before they fall. You may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and bone pain.1

High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. (Your doctor will monitor your blood sugar during treatment). An increased risk of heart attack, sudden death, and stroke can also occur. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.1

Reports of convulsions have occurred in patients taking LUPRON DEPOT with or without a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medicines that cause convulsions.1

You should also know that LUPRON DEPOT may cause impotence.1

Treatment affects all men differently. Talk to your doctor about your medical history and all other medicines you take. 

OTHER IMPORTANT CONSIDERATIONS

LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat1.

If you are concerned about any side effects or new symptoms during your LUPRON DEPOT treatment, it’s important to discuss them with your doctor right away.

Use 1

  • LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the palliative treatment of advanced prostate cancer.
  • LUPRON DEPOT is a prescription medication that must be administered in your doctor’s office.

Important Safety Information1

  • LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
  • LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
    • – Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and/or bone      pain.
    • – If your cancer has spread to the spine or urinary tract, urinary blockage or pressure on the spine may occur and can sometimes lead to paralysis, which may be life-threatening.
    • – You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
  • High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. Your doctor will monitor your blood sugar during treatment.
  • Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
  • LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
  • Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
  • Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
  • LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
  • LUPRON DEPOT may cause impotence.
  • The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

US-LUPR-181868

Please click here for Full Prescribing information.

123456

References: 1. LUPRON DEPOT® [package insert]. North Chicago, IL: AbbVie Inc. 2. Data on file. AbbVie Inc. IMS Health, IMS National Prescription Audit; January 2016-December2016. 3. U.S. Food and Drug Administration. Orange Book detail search. Available at http://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm. Accessed March 16, 2018. 4. National Cancer Institute. Prostate Cancer Treatment (PDQ [insert R ball])-Patient Version. Available at https://www.cancer.gov/types/prostate/patient/prostate-treatment-pdq?redirect=true#section/all. Accessed December 6, 2018.  

US-LUPR-181818

IMPORTANT SAFETY INFORMATION1

  • LUPRON DEPOT® (leuprolide acetate for depot suspension) is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.

  • LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.

    • – Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and/or bone pain.
    • – If your cancer has spread to the spine or urinary tract, urinary blockage or pressure on the spine may occur and can sometimes lead to paralysis, which may be life-threatening.
    • – You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
  • High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. Your doctor will monitor your blood sugar during treatment.

  • Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.

  • LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.

  • Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.

  • Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.

  • LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.

  • LUPRON DEPOT may cause impotence.

  • The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

Please click here for Full Prescribing information.

 

USE1

  • LUPRON DEPOT 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the palliative treatment of advanced prostate cancer.

  • LUPRON DEPOT is a prescription medication that must be administered in your doctor’s office.

IMPORTANT SAFETY INFORMATION1

LUPRON DEPOT® (leuprolide acetate for depot suspension) is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy. Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and/or bone pain. If your cancer has spread to 

IMPORTANT SAFETY INFORMATION1

  • LUPRON DEPOT is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
  • LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
    • –Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and/or bone      pain.
    • – If your cancer has spread to the spine or urinary tract, urinary blockage or pressure on the spine may occur and can sometimes lead to paralysis, which may be life-threatening.
    • – You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
  • High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. Your doctor will monitor your blood sugar during treatment.
  • Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
  • LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
  • Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.
  • Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
  • LUPRON DEPOT may cause fetal harm if administered to a pregnant woman.
  • LUPRON DEPOT may cause impotence.
  • The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reaction/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

For more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

US-LUPR-181868

Please click here for Full Prescribing information.

IMPORTANT SAFETY INFORMATION1

LUPRON DEPOT® (leuprolide acetate for depot suspension) is not for people who have had any type of allergic reaction to LUPRON DEPOT or similar drugs. LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.

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