Lupron Depot Side Effects

What to expect during the first few weeks

During the first few weeks of Lupron Depot therapy, testosterone levels will increase before they fall. Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and bone pain. If your cancer has spread to the spine or urinary tract, urinary blockage or pressure in the spine may occur and can sometimes lead to paralysis, which may be life threatening. You may require close medical attention during the first few weeks of Lupron Depot therapy. Notify your doctor if you develop new or worsened symptoms after beginning treatment.1

The most common side effects from Lupron Depot

  • Hot flashes or sweats
  • Injection site reactions or pain
  • General pain
  • Swelling
  • Testicular shrinkage
  • Difficulty urinating
  • Fatigue or weakness
  • Headache
  • Joint, gastrointestinal (GI), and
    respiratory problems

High blood sugar and increased risk of diabetes can occur in men using Lupron Depot. An increased risk of heart attack, sudden death, and stroke can also occur.

Reports of convulsions have occurred in patients taking LUPRON DEPOT with or without a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), or in those taking medicines that cause convulsions.

You should also know that Lupron Depot may cause impotence.

Other important considerations

LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.

If you are concerned about any side effects or new symptoms during your Lupron Depot treatment, it’s important to discuss them with your doctor right away.

  • Do Not Take If
    • You should not take LUPRON DEPOT if you have had any type of allergic reaction to LUPRON DEPOT or similar drugs.
    • Females who are or may become pregnant should not receive any formulation of LUPRON DEPOT.

    Reference:
    LUPRON DEPOT 7.5 mg for
    1-month, 22.5 mg for 3-month,
    30 mg for 4-month, and 45 mg for 6-month [package insert].

  • Before Starting
    • Talk to your doctor about your medical history and all other medicines that you take.
    • Increased risk of heart attack, sudden death, and stroke can occur in men using LUPRON DEPOT. Discuss this increased risk with your doctor before starting treatment and report any new symptoms during treatment.
    • LUPRON DEPOT can affect the electrical activity of your heart. Your doctor must determine if the benefits of using LUPRON DEPOT outweigh the risks, especially if you have congenital long QT syndrome, abnormal blood tests for electrolytes, congestive heart failure, or if you take medications to regulate your heartbeat.
    • Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in those taking medications associated with convulsions. Convulsions have also been reported in patients without any of these conditions.

    Reference:
    LUPRON DEPOT 7.5 mg for
    1-month, 22.5 mg for 3-month,
    30 mg for 4-month, and 45 mg for 6-month [package insert].

  • What to Expect
    • LUPRON DEPOT causes an increase in testosterone during the first few weeks of therapy.
      • Some men may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and/or bone pain.
      • If your cancer has spread to the spine or urinary tract, urinary blockage or pressure on the spine may occur and can sometimes lead to paralysis, which may be life-threatening.
      • You may require close medical attention during the first few weeks of therapy. Notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.
    • High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. Your doctor will monitor your blood sugar during treatment.
    • Regular blood tests are needed to check your testosterone and prostate-specific antigen (PSA) levels.
    • LUPRON DEPOT may cause impotence.

    Reference:
    LUPRON DEPOT 7.5 mg for
    1-month, 22.5 mg for 3-month,
    30 mg for 4-month, and 45 mg for 6-month [package insert].

  • Side Effects
    • The most common side effects of LUPRON DEPOT include hot flashes/sweats; injection site reactions/pain; general pain; swelling; testicular shrinkage; difficulty urinating; fatigue/weakness; headache; and joint, gastrointestinal, and respiratory problems.

    For more information, talk with your healthcare provider.

    Reference:
    LUPRON DEPOT 7.5 mg for
    1-month, 22.5 mg for 3-month,
    30 mg for 4-month, and 45 mg for 6-month [package insert].

  • Helpful Resources

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

    If you cannot afford your medication, contact www.pparx.org for assistance.

    View the full Prescribing Information for LUPRON DEPOT at www.rxabbvie.com/pdf/
    lupronuro_pi.pdf
    .

    Reference:
    LUPRON DEPOT 7.5 mg for
    1-month, 22.5 mg for 3-month,
    30 mg for 4-month, and 45 mg for 6-month [package insert].

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Safety Facts
  • LUPRON DEPOT 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month administration are prescribed for the palliative treatment of advanced prostate cancer.
  • LUPRON DEPOT is a prescription medication that must be administered in your doctor’s office.
Reference:
LUPRON DEPOT 7.5 mg for 1-month, 22.5 mg for 3-month, 30 mg for 4-month, and 45 mg for 6-month [package insert].

Reference:

  1. Lupron Depot® [package insert].